RISCOE, Michael K.: search on Z-Library

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1

Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

Potharaju, Suresh, Mutyam, Shravan Kumar, Liu, Mingtao, Green, Carol, Frueh, Lisa, Nilsen, Aaron, Pou, Sovitj, Winter, Rolf, Riscoe, Michael K., Shankar, Gita

Journal:

Pharmaceutical Development and Technology

Year:

2020

File:

PDF, 1.14 MB

2020

2

Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide

Jennifer E. Flythe, Jose F. Rueda, Michael K. Riscoe, Suzanne Watnick

Journal:

American Journal of Kidney Diseases

Year:

2009

Language:

english

File:

PDF, 439 KB

english, 2009

3

Evaluation and lead optimization of anti-malarial acridones

Rolf W. Winter, Jane X. Kelly, Martin J. Smilkstein, Rozalia Dodean, Grover C. Bagby, R. Keaney Rathbun, Joshua I. Levin, David Hinrichs, Michael K. Riscoe

Journal:

Experimental Parasitology

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

4

Mechanism of action of 5'-methylthioadenosine in S49 cells

Michael K. Riscoe, Paula A. Tower, Adolph J. Ferro

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 662 KB

english, 1984

5

Targeting the Cytochrome bc 1 Complex of Leishmania Parasites for Discovery of Novel Drugs

Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K., Ullman, Buddy, Landfear, Scott M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 3.29 MB

english, 2016

6

A spectroscopic investigation of the binding interactions between 4,5-dihydroxyxanthone and heme

Jane Xu Kelly, Rolf Winter, Michael Riscoe, David H Peyton

Journal:

Journal of Inorganic Biochemistry

Year:

2001

Language:

english

File:

PDF, 262 KB

english, 2001

7

Structural Snapshots of MTA/AdoHcy Nucleosidase Along the Reaction Coordinate Provide Insights into Enzyme and Nucleoside Flexibility During Catalysis

Jeffrey E. Lee, G.David Smith, Cathy Horvatin, David J.T. Huang, Kenneth A. Cornell, Michael K. Riscoe, P.Lynne Howell

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 1.10 MB

english, 2005

8

Mutational Analysis of a Nucleosidase Involved in Quorum-Sensing Autoinducer-2 Biosynthesis †

Lee, Jeffrey E., Luong, Winnie, Huang, David J. T., Cornell, Kenneth A., Riscoe, Michael K., Howell, P. Lynne

Journal:

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

9

Optimization of endochin-like quinolones for antimalarial activity

Rolf Winter, Jane X. Kelly, Martin J. Smilkstein, David Hinrichs, Dennis R. Koop, Michael K. Riscoe

Journal:

Experimental Parasitology

Year:

2011

Language:

english

File:

PDF, 727 KB

english, 2011

10

Characterization of RecombinantEschericha coli5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase: Analysis of Enzymatic Activity and Substrate Specificity

Kenneth A. Cornell, William E. Swarts, Ronald D. Barry, Michael K. Riscoe

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 232 KB

english, 1996

11

Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae

CORNELL, Kenneth A., WINTER, R. W., TOWER, Paula A., RISCOE, Michael K.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 461 KB

english, 1996

12

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

Janowsky, Aaron, Eshleman, Amy J., Johnson, Robert A., Wolfrum, Katherine M., Hinrichs, David J., Yang, Jongtae, Zabriskie, T. Mark, Smilkstein, Martin J., Riscoe, Michael K.

Journal:

Psychopharmacology

Year:

2014

Language:

english

File:

PDF, 642 KB

english, 2014

13

Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design †

Lee, Jeffrey E., Settembre, Ethan C., Cornell, Kenneth A., Riscoe, Michael K., Sufrin, Janice R., Ealick, Steven E., Howell, P. Lynne

Journal:

Year:

2004

Language:

english

File:

PDF, 756 KB

english, 2004

14

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

Martin J. Smilkstein, Isaac Forquer, Atsuko Kanazawa, Jane Xu Kelly, Rolf W. Winter, David J. Hinrichs, David M. Kramer, Michael K. Riscoe

Journal:

Molecular and Biochemical Parasitology

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

15

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Gimenez, Valéria M.M., Alvarenga, Tavane A., Groppo, Milton, Silva, Márcio L.A. e, Cunha, Wilson R., Januário, Ana H., Smilkstein, Martin J., Riscoe, Michael K., Pauletti, Patricia M.

Journal:

Revista Brasileira de Farmacognosia

Year:

2018

Language:

english

File:

PDF, 433 KB

english, 2018

16

Hydroxy-anthraquinones as antimalarial agents

R.W. Winter, Kenneth A. Cornell, Linda L. Johnson, Loren M. Isabelle, David J. Hinrichs, Michael K. Riscoe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 337 KB

english, 1995

17

A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum

Burgess, Steven J., Selzer, Audrey, Kelly, Jane Xu, Smilkstein, Martin J., Riscoe, Michael K., Peyton, David H.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

18

The kinetics of uptake and accumulation of 3,6-bis-ω-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum

Jane Xu Kelly, R.W Winter, Anda Cornea, David H Peyton, David J Hinrichs, Michael Riscoe

Journal:

Molecular and Biochemical Parasitology

Year:

2002

Language:

english

File:

PDF, 389 KB

english, 2002

19

Arginase is Essential for Survival of Leishmania donovani Promastigotes but not Intracellular Amastigotes

Boitz, Jan M., Gilroy, Caslin A., Olenyik, Tamara D., Paradis, Dustin, Perdeh, Jasmine, Dearman, Kristie, Davis, Madison J., Yates, Phillip A., Li, Yuexin, Riscoe, Michael K., Ullman, Buddy, Roberts,

Journal:

Infection and Immunity

Year:

2016

Language:

english

File:

PDF, 2.86 MB

english, 2016

20

A targeted structure-activity analysis of endochin-like quinolones reveals potent Q i and Q o site inhibitors of Toxoplasma gondii and Plasmodium falciparum cytochrome bc 1 and identifies ELQ-400 as a remarkably effective compound against acute experimental toxoplasmosis.

McConnell, Erin V., Bruzual, Igor, Pou, Sovitj, Winter, Rolf W., Dodean, Rozalia A., Smilkstein, Martin J., Krollenbrock, Alina, Nilsen, Aaron, Zakharov, Lev N., Riscoe, Michael K., Doggett, J. Stone

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 2.96 MB

english, 2018

21

Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-quinolone-3-diarylethers and Antimycin in Toxoplasma gondii

Alday, P. Holland, Bruzual, Igor, Nilsen, Aaron, Pou, Sovitj, Winter, Rolf, Ben Mamoun, Choukri, Riscoe, Michael K, Doggett, J. Stone

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 722 KB

english, 2016

22

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

Ling, Liqin, Mulaka, Maruthi, Munro, Justin, Dass, Swati, Mather, Michael W., Riscoe, Michael K., LlinÃ¡s, Manuel, Zhou, Jing, Ke, Hangjun

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.56 MB

2020

23

Xanthones as antimalarial agents; studies of a possible mode of action

Marina V. Ignatushchenko, R.W. Winter, Hans Peter Bächinger, David J. Hinrichs, Michael K. Riscoe

Journal:

Year:

1997

Language:

english

File:

PDF, 692 KB

english, 1997

24

Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone

Rozalia A. Dodean, Jane X. Kelly, David Peyton, Gary L. Gard, Michael K. Riscoe, Rolf W. Winter

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

25

Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye

Jane X. Kelly, Rolf W. Winter, Theodore P. Braun, Myralyn Osei-Agyemang, David J. Hinrichs, Michael K. Riscoe

Journal:

Experimental Parasitology

Year:

2007

Language:

english

File:

PDF, 695 KB

english, 2007

26

Cloning and expression of Escherichia coli 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase: Identification of the pfs gene product

Kenneth A Cornell, Michael K Riscoe

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 435 KB

english, 1998

27

The Coat and Cylindrical Inclusion Proteins of a Potyvirus Are Associated with Connections between Plant Cells

Emilio Rodrı&amp, #x0301, guez-Cerezo, Kim Findlay, John G. Shaw, George P. Lomonossoff, Shirley G. Qiu, Paul Linstead, Michael Shanks, Cristina Risco

Journal:

Year:

1997

Language:

english

File:

PDF, 3.74 MB

english, 1997

28

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

Rolf W. Winter, Jane X. Kelly, Martin J. Smilkstein, Rozalia Dodean, David Hinrichs, Michael K. Riscoe

Journal:

Experimental Parasitology

Year:

2008

Language:

english

File:

PDF, 438 KB

english, 2008

29

The comparative effects of 5′-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5′-methylthioadenosine phosphorylase

White, Michael W., Riscoe, Michael K., Ferro, Adolph J.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1983

Language:

english

File:

PDF, 710 KB

english, 1983

30

Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

R.W. Winter, Kenneth A. Cornell, Linda L. Johnson, Michael K. Riscoe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 310 KB

english, 1993

31

Atovaquone and ELQ-300 combination therapy: A novel dual-site cytochrome bc 1 inhibition strategy for malaria

Stickles, Allison M., Smilkstein, Martin J., Morrisey, Joanne M., Li, Yuexin, Forquer, Isaac P., Kelly, Jane X., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Vaidya, Akhil B., Riscoe, Michael K.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

32

Potentiation of an antimalarial oxidant drug

Winter, R. W., Ignatushchenko, Marina, Ogundahunsi, Olumide a T, Cornell, Kenneth a., Oduola, Ayoade M J, Hinrichs, David J., Riscoe, Michael K.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1997

Language:

english

File:

PDF, 321 KB

english, 1997

33

Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil

van Schalkwyk, Donelly A., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Duffey, MaÃ«lle, Moon, Robert W., Sutherland, Colin J.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 984 KB

2020

34

α lipoic acid inhibits human T-cell migration: Implications for multiple sclerosis

Gail H. Marracci, Gabriel P. McKeon, Whitney E. Marquardt, Rolf W. Winter, Michael K. Riscoe, Dennis N. Bourdette

Journal:

Journal of Neuroscience Research

Year:

2004

Language:

english

File:

PDF, 210 KB

english, 2004

35

Antileishmanial drug development: exploitation of parasite heme dependency

Jane Xu Kelly, Marina V Ignatushchenko, H.G Bouwer, David H Peyton, David J Hinrichs, R.W Winter, Michael Riscoe

Journal:

Molecular and Biochemical Parasitology

Year:

2003

Language:

english

File:

PDF, 205 KB

english, 2003

36

Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

Silva, Marta G., Bastos, Reginaldo G., Stone Doggett, J., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Nilsen, Aaron, Suarez, Carlos E.

Journal:

Parasites & Vectors

Year:

2020

File:

PDF, 1.70 MB

2020

37

Pyrimethamine resistant?

Journal:

Parasitology Today

Year:

1990

Language:

english

File:

PDF, 118 KB

english, 1990

38

Structure of E. coli 5′-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases

Jeffrey E. Lee, Kenneth A. Cornell, Michael K. Riscoe, P.Lynne Howell

Journal:

Year:

2001

Language:

english

File:

PDF, 685 KB

english, 2001

39

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

Doggett, J Stone, Schultz, Tracey, Miller, Alyssa J., Bruzual, Igor, Pou, Sovitj, Winter, Rolf, Dodean, Rozalia, Zakharov, Lev N, Nilsen, Aaron, Riscoe, Michael K, Carruthers, Vern B

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 1.46 MB

2020

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